| abstract |
10'-[ω-N-/1,4-diazabicyclo (4,m,O)-alkanyl/-acyl]-Phenothiazines having the formula: ##STR1## wherein X=H, Cl, or CF 3 ; n = 1, 2 or 3; and m = 3 or 5; and their pharmaceutically acceptable acidic addition and quaternary salts are pharmacologically active. The most active compound 10'[βN-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propionyl]-2'-chlorophenothiazine of the formula: ##STR2## is useful as the active ingredient of a medicated compound possessing spasmolytic and coronary-dilatant effect. n The process for producing said compounds comprises reacting an ω-chloracyl -2-substituted phenothiazine with a 1, 4-diazabicyclo-(4,m,O)-alaken in an inert solvent medium at a temperature of 50°-140° C followed by isolation of the desired product. |