http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3984461-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_288b0bf6f4d87f95c10350b70c6a311c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-40 |
| filingDate | 1972-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1976-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d559d05aca1c5a7ca4a5b1770b1b1914 |
| publicationDate | 1976-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3984461-A |
| titleOfInvention | 3-0-(Beta-carbobenzyloxypropionyl)-11-oxo-18-beta-olean-12-en-30-oic acid |
| abstract | A two-step method for the preparation of 3-0-(beta-carboxypropionyl-18-beta-glycyrrhetic acid (carbenoxolone) is disclosed, which comprises the steps of condensing beta-glycyrrhetic acid with anhydrous beta-carbobenzyloxypropionic acid (or a derivative thereof such as its chloride or anhydride), the result being 3-O-(beta-carbobenzyloxypropionyl)-11-oxo-18-beta-olean-12-en-30-oic acid, the latter compound being then debenzylated with hydrogen under normal temperature and pressure conditions, in an alcoholic solvent (alcohols having from C 1 to C 5 ) and in the presence of catalytic amounts of a noble metal (e.g. palladium), thus obtaining the expected compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4173648-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4448788-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4530934-A |
| priorityDate | 1971-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.