| abstract |
Arginine or lysine salt of acid cephalosporins can be administered parenterally, e.g., by intramuscular injection, with no substantial pain. Preferred acid cephalosporin salts are l-arginine or lysine salts of N-[7-( alpha -sulfophenylacetamido)ceph-3-em-3-ylmethyl]-pyridinium-4-carboxylate, N-[7-( alpha -sulfophenylacetamido)-ceph-3-em-3-ylmethyl]-(4'-carbamoyl)pyridinium 4-carboxylate, 7-cyanoacetamido-cephalosporanic acid, 7-(2'-thienylacetamido)-3-[6''-(3''-methylpyridazinyl)thiomethyl]-ceph -3-em-4-carboxylic acid 2''-oxide, 7-tetrazolylacetamido-3-[5'-(2'-methylthiadiazolyl)thiomethyl]-ceph-3- em-4-carboxylic acid and 7-(2'-thienylacetamido)-cephalosporanic acid. |