http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3971775-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-12 |
| filingDate | 1975-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1976-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dddf35ab80516a350c60024e6a83c4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fabaac532d494f9ca9081b19adc3c30 |
| publicationDate | 1976-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3971775-A |
| titleOfInvention | Process for preparing penicillin antibiotics |
| abstract | α-Aminoacylpenicillin antibiotics such as ampicillin and amoxycillin may be prepared in particularly simple manner by a process which comprises preparing a solution of 6-aminopenicillanic acid (6-APA) in a water-immiscible organic solvent by treating 6-APA with an excess of a strong tertiary amine base in the presence of said solvent; neutralising the residual strong tertiary amine base in said solution; reacting the neutralised solution with a solution in a water-immiscible organic solvent of an acylating agent which is a mixed anhydride of a lower alkoxyformic acid and an N-protected derivative of an α-aminoacid wherein the N-protecting group is acid-labile, to yield a solution of an N-protected α-aminoacylpenicillin derivative; contacting the resulting solution with water and a strong acid to cleave the acid-labile N-protecting group; and isolating the thus-obtained α-aminoacylpenicillin from the resulting water-containing system. The use of water-immiscible solvents in the process obviates the need for a solvent evaporation stage during isolation of the α-aminoacylpenicillin product and thus renders the process of particular advantage in plant-scale operations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4366098-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4193918-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5840885-A |
| priorityDate | 1974-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.