| abstract |
α-D-6-methylergolinyl-8-acetamides of the formula: ##SPC1## n Are readily prepared from α-D-6-methylergolinyl-8-acetic acid azide hydrochloride and amines of the formula R 1 -NH-R 2 and may be converted to their salts with inorganic and organic acids by neutralization. In these formulas, R 1 may be hydrogen or lower alkyl, R 2 may be hydrogen, lower alkyl, cycloalkyl having 5 or 6 carbon atoms, hydroxyalkyl having 3 or 4 carbon atoms, or lower alkoxycarbonylmethyl or R 1 and R 2 jointly may be divalent alkylene having 4 or 5 C atoms. The salts of most of these bases with physiologically tolerated acids are nontoxic in doses which suppress lactatical and prevent pregnancy in rats when applied orally after copulation. The others, equally non-toxic, extend the effective period of thiopental. |