| abstract |
Reaction of a 2-amino-, 2-alkylamino- or 2-dialkylamino-4-hydroxypyrimidine, preferably also containing a methyl group at the 6 position, with an aldehyde R--CHO in presence of hydrogen and a hydrogenation catalyst introduces an alkyl group R--CH 2 -- into the 5 position. The reaction is preferably carried out under superatmospheric pressure at a temperature between 80° and 180°C and is aided by metal salts, acids, amines, amine salts or basic ion-exchange resins. |