http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3936462-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-60 |
| filingDate | 1973-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1976-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06593aa3a9eb8f11f29db80a30c1512f |
| publicationDate | 1976-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3936462-A |
| titleOfInvention | 1,2,3,4,5,6-Hexahydro-1-oxo or hydroxy-3-acyl-2,6-methano-3-benzazocines and corresponding 1-esters thereof |
| abstract | 1,2,3,4,5,6-Hexahydro-1-oxo-3-(hydrocarbon or substituted hydrocarbon)-8-(H or OH)-6-(H or alkyl)-11-(H or alkyl)-2,6-methano-3-benzazocines and 1-hydroxy secondary and tertiary alcohols obtainable therefrom by reduction and by Grignard reactions, and esters of the same, are useful as central nervous system depressants, particularly as analgesics and as analgesic antagonists. The 3-substituent is introduced by alkylation, directly or by N-acylation followed by reduction of the resulting amides, of the corresponding >NH compounds either before or after introduction of the 1-oxo group into the compounds having two hydrogens at the 1-position by chromium (VI) oxidation. Various intermediates and derivatives are also descibed, including 3a,4,5,9b-tetrahydro-3,5-ethanonaphth[2,1-d]oxazol-2(3H)-ones obtained by interacting 1,2,3,4,5,6-hexahydro-1-hydroxy-2,6-methano-3-benzazocines with phosgene or by heating 1,2,3,4,5,6-hexahydro-1-hydroxy-3-carbalkoxy-2,6-methano-3-benzazocines with alkoxide ion. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4294840-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018507882-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004259901-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7271173-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4217354-A |
| priorityDate | 1972-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1136.