| abstract |
WHEREIN R is selected from the group consisting of phenyl, substituted phenyl and aralkyl; R1 is selected from the group consisting of hydrogen, lower alkyl, unsaturated lower alkyl, substituted lower alkyl and aralkyl; Y and Z are selected from the group consisting of O and S, but Y and Z are always dissimilar. The compounds of the present invention possess a high degree of pharmacological activities such as anti-inflammatory, anti-ulcerative, analgetic, antipyretic, antihistaminic and central nervous system depressive activities, and certain of them are useful as new anti-inflammatory agents, analgesics and central nervous system depressants. The pyrido(2,3-d)pyrimidinethiones of the present invention can be represented by the following formula: |