| abstract |
Novel 4''-Alkoxy- Beta -D-ribofuranosyl, 4''-alkoxy-2''-deoxyBeta -D-erythro-pentofuranosyl and 4''-alkoxy- Beta -Darabinofuranoxyl nucleosides and the corresponding 4''-haloalkoxy nucleosides can be prepared from the respective 4''-alkoxy-5''deoxy-5''-iodo- Beta -D-ribofuranosyl, 4''-alkoxy-2'', 5''-dideoxy5''-iodo- Beta -D-erythropentofuranosyl and 4''-alkoxy-5''-deoxy5''-iodo- Beta -D-arabinofuranosyl nucleosides. The novel 4''-alkoxy and 4''-haloalkoxy nucleosides are valuable pharmacological agents. For example, they are useful in regulating and controlling metabolism and for producting metabolic deficiencies in biological systems. |