| abstract |
A mixture of water-soluble salts of d- and 1-2-(6-methoxy-2naphthyl)propionic acid is treated with a salt of dehydroabietylamine, the crystallized dehydroabietylamine salt of the 1-isomer is removed leaving a mother liquor enriched in the water-soluble salt of the d-isomer, an inorganic salt more soluble in water than is the water-soluble salt of the d-isomer is added to the aqueous portion of the mother liquor, and the least water-soluble salt of the d-isomer is crystallized from the aqueous portion. The crystallized salt of the d-isomer is redissolved in water and acidified to yield substantially pure disomer, which has anti-inflammatory, anti-pyretic and analgesic activities. |