| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00 |
| filingDate |
1972-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1975-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6154a2c4e90b8a3705355fa443f87717 |
| publicationDate |
1975-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-3903150-A |
| titleOfInvention |
Process for preparing 3-fluoro-D-alanine |
| abstract |
3-Fluoro-D-analine is prepared by an asymmetric synthesis wherein fluoroacetaldehyde is reacted with D-optically active amine, such as D- Alpha -methylbenzylamine to form the corresponding acetaldimine, which is reacted with hydrogen cyanide to form D-2-(D- Alpha -methylbenzylamino)-3fluoropropionitrile, followed by hydrolysis of the nitrile and hydrogenolysis of the methylbenzyl group. Other D-optically active amines such as R(D)-phenyl-glycine and 1-amino-(S)-2-((R)1-hydroxyethyl)indoline may be employed in the above process in place of the D- Alpha -methyl-benzyl amine. The 3-fluoro-Dalanine thus obtained is a potent antibacterial agent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5319096-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002187068-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6436344-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0132224-A1 |
| priorityDate |
1972-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |