http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3897431-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-1742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-174 |
| filingDate | 1973-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1975-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_853506b45de3d56e44eb379b5d222913 |
| publicationDate | 1975-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3897431-A |
| titleOfInvention | 2-{8 {60 -Alkoxy-arylmethyl{9 -2-imidazolines and -1,4,5,6-tetrahydropyrimidines |
| abstract | 2-( Alpha -(Lower-alkoxy)- Alpha -R1-Ar-methyl)-2-imidazolines, -1,4,5,6-tetrahydropyrimidines and -4,5,6,7-tetrahydro-1H-1,3diazepines, having pharmacological properties, e.g., hypoglycemic, diuretic, anti-inflammatory, are prepared by heating a 2-(lower-alkoxy)-2-Ar-alkanenitrile with an alkanediamine, wherein 2, 3 or 4 carbon atoms respectively intervene between the two amino groups, in the presence of a catalytic amount of carbon disulfide or hydrogen sulfide, where R1 is hydrogen, lower-alkyl or lower-alkenyl, Ar is phenyl, naphthyl, indanyl, biphenylyl, cyclohexenyl, cyclohexyl and phenyl substituted by from one to three substituents selected from lower-alkyl, lower-alkoxy, halo, trihalomethyl, loweralkylmercapto, lower-alkylsulfonyl, di-(lower-alkyl)amino, amino, hydroxy, nitro, hydroxyamino and benzyloxy. The intermediate 2(lower-alkoxy)-2-Ar-alkanenitriles are prepared preferably by first reacting an aldehyde of the formula Ar-CHO with a tri(lower-alkyl) orthoformate to form the aldehyde di-(lower-alkyl) acetal, reacting the latter with an acyl halide to form the corresponding Alpha -halo-Ar-methyl lower-alkyl ether and reacting said ether with an alkali cyanide to yield said intermediate nitrile. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0423802-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-627627-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5134154-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0210518-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4260626-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3966757-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0210518-A3 |
| priorityDate | 1969-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 271.