| abstract |
Compounds of the formula WHEREIN R1 is -OH; -COOH; -CONH2; -NO2; -CF3; halogen; alkyl of 4 to 5 carbon atoms; alkoxy of 4 to 5 carbon atoms; alkenyl of 3 to 5 carbon atoms; alkynyl of 2 to 5 carbon atoms; alkenyloxy of 3 to 5 carbon atoms; alkynyloxy of 3 to 5 carbon atoms; acyl; alkylthio of 1 to 4 carbon atoms; hydroxyalkyl of 1 to 5 carbon atoms; aryl; aryl-lower alkyl; aryloxy; arylamino; aryl-lower alkoxy; aryloxy-lower alkyl; cycloalkyl of 3 to 7 carbon atoms; alkoxyalkyl of 2 to 4 carbon atoms; alkylsulfonylamido of 1 to 4 carbon atoms; dialkylsulfonamido of 2 to 8 carbon atoms; -(CH2)x-CN; -(CH2)x-NH2; -(CH2)x-NH-COOR5; -(CH2)x-NH-acyl; -(CH2)x-NH-CO-NR6R7; -COOR; where X IS 0, 1, 2 OR 3, R is alkyl of 1 to 4 carbon atoms, R5 is alkyl of 1 to 3 carbon atoms, and R6 and R7 are each hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 3 to 5 carbon atoms or, together with each other and the nitrogen atom to which they are attached, a 5- to 6membered heterocycle; OR, WHERE R4 is other than hydrogen, also alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; R2 is hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms or alkenyloxy of 2 to 5 carbon atoms; R3 is hydrogen, halogen, alkyl of 1 to 5 carbon atoms or alkoxy of 1 to 5 carbon atoms; R2 and R3, together with each other, form a saturated or unsaturated carbocyclic ring or heterocyclic ring; R4 is hydrogen, alkyl of 1 to 5 carbon atoms or aralkyl; and N IS AN INTEGER FROM 1 TO 10, INCLUSIVE; AND THEIR NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS Beta ADRENERGIC BLOCKING AGENTS AND HYPOTENSIVES. |