| abstract |
A process for making 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones which comprises (a) coupling a diazotized arylamine with a lower alkyl cyanoacetate: (b) hydrolyzing and decarboxylating the lower alkyl cyanoglyoxalate arylhydrazone thus produced under alkaline conditions; and (c) cyclizing the resulting glyoxamide arylhydrazone by reaction with a dialkyl carbonate, an alkyl chloroformate or phosgene in the presence of a condensing agent to the corresponding 2-aryl-1,2,4-triazine-3,5(2H,4H)-dione. The products are useful as coccidiostats. |