| abstract |
Therapeutically useful cyclopentane derivatives, some of which are new, of the formula: WHEREIN R1 is alkyl, alkoxyalkyl, cycloalkyl or adamantyl, R2 is hydrogen, alkyl or carboxylic acyl, R3 is carboxy, alkoxycarbonyl, carbamoyl, carbazoyl, or carbamoyl or carbazoyl substituted by alkyl, R4 is oxygen, hydroxyimino alkoxyimino, hydrazono or alkyl-substituted hydrazono, R5 is alkyl or hydrogen, X is trans-vinylene or ethylene, and n is 5,6,7 or 8, are prepared by a new process involving few steps and as intermediates new compounds of the formula: WHEREIN A is a group OR C NOR8, in which R7 is alkyl or the symbols R7 together represent an ethylene or alkyl-substituted ethylene linkage, and R8 is alkyl. The cyclopentane derivatives are useful in the production of hypotension, bronchodilation, inhibition of gastric acid secretion, and stimulation of uterine contraction. |