| abstract |
New ethenoadenosine cyclicphosphate compounds are disclosed wherein the 1,N6 nitrogen atoms of the adenosine moiety bear an etheno or substituted etheno bridge group. Also disclosed are methods for the preparation of these compounds, which are useful as intracellular mediators of hormone effect in animals. 1,N6etheno-8-benzylthioadenosine 3'',5''-cyclicphosphate, 1,N6- Alpha propylethenoadenosine 3'',5''-cyclicphosphate, the 3''-cyclic ester of 1,N6-etheno-5''-deoxy-5''-dihydroxyphosphinylmethyladenosine, the 5''-cyclic ester of 1,N6-etheno-3''-deoxy-3''dihydroxyphosphinylmethyladenosine, 1, N6-etheno-9-(6-deoxy- Beta -D-allofuranosyl)adenine 3'',5''-cyclicphosphate, 1, N6-etheno-9(6-deoxy- Alpha -L-talofuranosyl)-adenine 3'',5''-cyclicphosphate, and 1, N6-etheno-5'',5''-di-C-methyladenosine 3'',5''-cyclicphosphate are illustrated as representative of the compound class. |