| abstract |
Compounds of the class of 6-phenyl-4H-s-triazolo(1,5a)(1,4)benzodiazepine-2-carboxamides, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anticonvulsive and anti-aggressive action and inhibit somatic reflexes. Specific embodiments are N,N-dimethyl-6-phenyl-8chloro-4H-s-triazolo(1,5-a)(1,4)benzodiazepine-2 -carboxamide, 6(o-fluorophenyl)-8-chloro-4H-s-triazolo(1,5a)(1,4)benzodiazepine-2 -carboxamide, N,N-dimethyl-6-(ofluorophenyl)-8-chloro-4H-s-triazolo (1,5-a)(1,4)benzodiazepine2-carboxamide and N,N-dimethyl-6-(o-chlorophenyl)-8-chloro-4H-striazolo(1,5 -a)(1,4)benzodiazepine-2-carboxamide. |