http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3860616-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00 |
| filingDate | 1972-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1975-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10cdb6775b650ef66c0ec12ac2f1cf74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9b0440fe4bac8eb16e9c6dedcd0d07 |
| publicationDate | 1975-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3860616-A |
| titleOfInvention | Synthesis of d,1-zearalanol |
| abstract | The preparation of d,1-zearalanol and mono- and di-ethers thereof, compounds exhibiting anabolic, estrogenic and fertility control properties, are prepared from readily available chemical intermediates. Catalytic reduction of the aliphatic double bond and the carbonyl moiety of 2-(10''-hydroxy-6''-oxo-1''-trans undecenyl)-4,6-dimethoxy benzoic acid affords a tetrahydro seco acid which is ring closed with trifluoroacetic anhdyride to yield d,1-zearalanol-2,4-dimethylether; cleavage of the diether is accomplished with boron tribromide to produce d,1-zearalanol. Alternatively, catalytic reduction of the aliphatic double bond of 2-(10''-hydroxy-6''-oxo-1''-trans undecenyl)-4,6-dimethoxy benzoic acid produces a dihydro seco acid which is ring closed with trifluoroacetic anhydride to yield d,1-zearalanone-2,4dimethyl ether; reduction of the carbonyl function affords d,1zearalanol-2,4-dimethyl ether which is reacted with boron tribromide to produce d,1-zearalanol. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008146545-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4751239-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067412-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4886899-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8301953-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8450305-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4902711-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011190237-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4690948-A |
| priorityDate | 1969-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.