| abstract |
THE ZWITTERION THEREOF OR THE HEMI-SALT THEREOF; R is alkyl of not more than 4 carbon atoms; and R1 is alkyl of not more than 8 carbon atoms in association with a pharmaceutical carrier. The compounds have clindamycin-like antibacterial activity and provide particularly high concentrations of compound in the urinary tract thereby being particularly useful in treating bacterial infections of the upper and lower urinary tract as well as L-forms in the kidney. OR THE ACID ADDITION SALTS THEREOF WHEREIN Halo is chlorine, bromine, or iodine, X is a member selected from the group consisting of hydrogen, an acyl radical of an aliphatic carboxylic acid having from 2 to 18 carbon atoms, inclusive, 1''-( Beta -Hydroxyethyl)-1''-demethylclindamycin compounds of the formula: |