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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08
filingDate 1972-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1974-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f320bf4d8e173c47790c108074d0107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_239daa2f6129a0e4c193420927a93596
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publicationDate 1974-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-3855202-A
titleOfInvention One step process for the production of a monoester of macrolide antibiotics
abstract A mono-ester of the antibiotic SF-837 substance and leucomycin A3 in which the hydroxyl group at the 10-position of the lactone ring of the molecule has been esterified can simply and effeciently be produced in one step by reacting the free base form of the SF-837 substance or leucomycin A3 with an acyl halide in solution in a selected solvent and in the presence of a selected acid-binding agent, in contrast to the previously known method of producing said mono-ester which needs two-stage reactions, namely the preparation of the di-ester and subsequent partial de-acylation of the di-ester.
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priorityDate 1972-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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