http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3847893-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate | 1973-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1974-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e82adc903ba4d14caa9f4c0ccc77aeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_565aec53c0c1a053fff224c46df940ad |
| publicationDate | 1974-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3847893-A |
| titleOfInvention | Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine |
| abstract | 1. A PROCESS FOR THE PREPARATION OF A BIFUNCTIONALLY CROSSLINKED INSULIN DERIVATIVE IN WHICH THE AMINO GROUP OF THE A-1 GLYCINE IS LINKED TO THE $AMINO GROUP OF THE B-29 LYSINE BY A BRIDGE OF THE FORMULA: -CO-X-COIN WHICH X IS A CARBON-CARBON-CARBON BOND, ALKYLENE OF 1 TO 15 CARBON ATOMS, OR ALKYLENE OF 1 TO 15 CARBON ATOMS WHEREIN 1 CARBON ATOM IS REPLACED BY SULPHUR, OXYGEN OR IMINO, SAID ALKYLENE BEING UNSUBSTITUTED OR SUBSTITUTED BY ONE OR TWO HYDROPHILLIC GROUPS WHICH COMPRISES THE STEPS OF REACTING THE INSULIN A-CHAIN IN WHICH THE FOUR FREE MERCAPTO GROUPS HAVE BEEN PROTECTED, WITH AN ACTIVATED DERIVATIVE OF A DISCARBOXYLIC ACID OF THE FORMULA: Z-CO-X-CO-Z IN WHICH X IS AS ABOVE DEFINED AND Z IS A SUITABLE ACID ACTIVATING GROUP, TO PRODUCE AN INSULIN A-CHAIN DERIVATIVE MONOFUNCTIONALLY SUBSTITUTED ON THE AMINO GROUP OF TIVATED DERIVATIVE OF A DICARBOXYLIC ACID OF THE FORMULA: B-CHAIN IN WHICH THE TWO FREE MERCAPTO GROUPS HAVE BEEN PROTECTED, TO YIELD A COMPOUND OF THE FORMULA: ASN(A21)-(CYS(-S-Y))4-GLY(A1)-NH-CO-X-CO-NHLYS(B29)(-ALA)-CYS(-S-Y)-CYS(-S -Y)-PHE(B1)-NH2 IN WHICH X IS AS ABOVE DEFINED AND Y IS THE MERCAPTO PROTECTING GROUP, REMOVING THE MERCAPTO GROUPS, AND OXIDIZING THE MERCAPTO GROUPS IN AN AQUEOUS ALKALINE MEDIUM TO FORM DISULFIDE BONDS. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4430266-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE36359-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015083114-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3662926-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3953417-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6001604-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10195287-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105793283-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618049-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017248496-B2 |
| priorityDate | 1972-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.