| abstract |
1. A PROCESS FOR THE PREPARATION OF 1-SUBSTITUTED-2ALKYL POLYHYDROISOQUINOLINES CONSISTING ESSENTIALLY OF REACTING A SUBSTITUTED N-ALKYL POLYHYDROISOQUINOLINIUM SALT HAVING THE FOLLOWING FORMULA: 1-(A-N(+)(-R)-CH2-),4-X-BENZENE Z(-) WHERE R IS METHYL, A, TAKEN WITH N, IS AN OCTAHYDROISOQUINOLINE, HEXAHYDROISOQUINOLINE OR TETRAHYDROISOUINOLINE RESIDUE, Z IS A HALIDE OR TOSYLATE ION, AND X IS LOWER ALKYL, LOWER ALKOXY OR HYDROGEN, WITH AN ALKALI METAL HYDRIOXIDE, ALCOHOLATE HAVING UP TO 6 CARBONS; CARBONATE OR BICARBONATE, IN AN INERT SOLVENT, AT A TEMPERATURE OF FROM ABOUT 130*C. TO ABOUT 170*C. |