http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3838156-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
filingDate | 1973-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1974-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56a841ae04beb1787e698cc1d0e7f3aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7aca30c1ec749f8e00b4291eedcb2d9 |
publicationDate | 1974-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-3838156-A |
titleOfInvention | Certain 2-substituted-6-(3 or 4-pyridyl)-nicotinic acid derivatives |
abstract | INTERMEDIATE 2-R1 NH-6-Q''''''-NICOTINIC ACID (V''), WHERE R1 IS LOWER-ALKYL AND Q'''''' IS 4(OR 3) -PYRIDYL OR 4(OR 3)PYRIDYL HAVING ONE OR TWO LOWER-ALKYL SUBSTITUENTS, IS PREPARED IN THE THREE STEPS OF: HYDROLYZING 1,2-DIHYDRO-2OXO-6-Q''''''-NICOTINONITRILE (VII)TO PRODUCE 1,2-DIHYDRO-2 OXO-6-Q''''''-NICOTINIC ACID (VIII), HALOGENATING VIII TO PRODUCE 2-HALO-6Q''''''-NICOTINIC ACID (VI''), AND, REACTING VI'' WITH R1NH2 TO PRODUCE V''. ALSO SHOWN ARE THE STEPS OF: REACTING 2-HALO-6-Q''''-NICOTINIC ACID (VI''), AND, REACTING IS AS Q'''''' AND ALSO LOWER-ALKYL, TO PRODUCE 2-R1 NH-6-Q''''NICOTINIC ACID (V), HEATING V WITH A LOWER-ALKYL CHLOROFORMATE OR PHOSGENE TO PRODUCE 1-R1-7-Q''''-1H,4H-PYRIDO(2,3-D)(1,3) OXAZINE-2,4-DIONE (I''), CONVERTING I'' WHERE Q'''' IS CH3 TO ITS 8-OXIDE AND REACTING THE 8-OXIDE WITH A LOWER -ALKANOIC ACID ANHYDRIDE TO PRODUCE I WHERE 7-CH3 IS CONVERTED TO 7-(LOWER-ALKANOYLOYMETHYL), REACTING 1 -R1 -7-Q-1H,4H-PRIDO(2,3-D)(1,3)OXAZINE-2,4-DIONE, WHERE Q IS AS Q'''' AND ALSO LOWER-ALKANOYLOXYMETHYL, WITH R2-C(=O)CH2COOR, WHERE R2 IS H OR CH3 AND R IS LOWER-ALKYL, TO PRODUCE LOWER-ALKYL 1-R1-1,4-DIHYDRO-2R2-4-OXO-7-Q-1,8-NAPHTHYRIDINE-3-CARBOXYLATE (III), AND, HYDROLYZING III TO OBTIN 1-R,1,4-DIHYDRO-2-R2-4-OXO-7Q''-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID (IV), WHERE Q'' IS LIKE Q BUT HAVING HYDROXYMETHYL IN PLACE OF LOWERALKANOYLOXYMETHYL. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4515945-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008030408-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008030408-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010204203-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4225715-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008204412-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4317909-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4294836-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4297360-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4524203-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009220586-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008084223-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8084471-B2 |
priorityDate | 1973-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 221.