abstract |
QUININE, QUINIDINE AND ANALOGS THEREOF, ARE PREPARED BY REACTING A 4-QUINOLYLLITHIUM COMPOUND WITH A 4,5-ERYTHRO5-ETHYL-(OR VINYL)-QUINUCLIDINE - 2E - CARBOXALDEHYDE OR THE CORRESPONDING QUINUCLIDINE-2-CARBOXYLIC ACID ALKYL ESTER. ALSO DESCRIBED,INTERALIA, IS THE PREPARATION OF A 4,5-ERYTHRO-5-ERYL-(OR VINYL)-QUINUCLIDIN-2-CARBOXALDEHYDE, AND A 4,5-ERYTHRO-5-ETHYL-(OR VINYL)-QUINUCLIDINE-2CARBOXYLIC ACID AND ESTERS THEREOF. THE END PRODUCTS ARE USEFULS AS ANTIMALARIAL AND ANTIARRHYTHMIC AGENTS. |