http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3812112-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-18 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 |
filingDate | 1971-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1974-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4b2dbaf714c85e71724cdec44ef42a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f9f51232b2d0be1e303320a023f93a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8cc0e685d9a9bdeb3d961c8587c12ef |
publicationDate | 1974-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-3812112-A |
titleOfInvention | Indolylacetic acid derivatives |
abstract | NOVEL INDOLYLACETIC ACID DERIVATIVES, WHICH HAVE EXCELLENT ANTI-INFLAMMATORY, ANTIPYRETIC AND ANALGESIC ACTIVITIES, REPRESENTED BY THE FORMULA, 1-(R3-(A)M-CO-),2-R2,3-(R4-OOC-CH(-R1)-),5,6-(-X1-(CH2)N- X2-)INDOLE 1,2-(-X1-(CH2)N-X2-),4-(B=N-NH-)BENZENE WHEREIN X1, X2 AND N ARE THE SAME AS DEFINED ABOVE AND B IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF (-H)2 AND X (WHEREIN Z IS A NITROGEN PROTECTING SYSTEM COMPRISING AT LEAST ONE READILY REMOVABLE GROUP), WITH AN ACID HALIDE REPRESENTED BY THE FORMULA, R3-(A)M-CO-HAL WHEREIN R3, A AND M ARE THE SAME AS DEFINED ABOVE AND HAL IS HALOGEN, TO OBTAIN N1-ACYLATED COMPOUND OF THE FORMULA, 1,2-(-X1-(CH2)N-X2-),4-(R3-(A)M-CO-N(-N=B)-)BENZENE WHEREIN X1, X2 R3, A, B, M AND N ARE THE SAME AS DEFINED ABOVE, THEN REACTING THE RESULTANT N1-ACYLATED COMPOUND (II) WITH AN ALIPHATIC ACID DERIVATIVE REPRESENTED BY THE FORMULA, R2-CO-CH2-CH(-R1)-COO-R4 WHEREIN R1, R2 AND R4 ARE THE SAME AS DEFINED ABOVE. WHEREIN X1 AND X2 EACH IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF OXYGEN AND METHYLENE; A IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF UNSUBSTITUTED SATURATED HYDROCARBON CHAIN HAVING UP TO 5 CARBON ATOMS, UNSUBSTITUTED UNSATURATED HYDROCARBON CHAIN HAVING UP TO 5 CARBON ATOMS AND SUBSTITUTED SATURATED OR SUBSTITUTED ETHYLENICALLY UNSATURATED HYDROCARBON CHAIN HAVING UP TO 5 CARBON ATOMS AND SUBSTITUTED SATURATED STITUENTS ARE SELECTED FROM THE GROUP CONSISTING OF HALOGEN OR PHENYL, THE HYDROCARBON CHAIN BEING STRAIGHT OR BRANCHED ONE; M IS 0 OR 1; N IS 1 OR 2; R1 AND R2 EACH IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL HAVING UP TO 4 CARBON ATOMS; R3 IS A MEMBER SELECTED FROM THE GOUP CONSISTING OF ALKYL HAVING UP TO 4 CARBON ATOMS UNSUBSTITUTED OR A LOWER ALKYL-, LOWER ALKKOXY-, LOWER ALKYLTHIO-, NITRO-, METHYLENEDIOXY-, ETHYLENEDIOXY- OR HALOGEN-SUBSTITUTED ARYL, EACH OF SAID ALKYL, ALKOXY AND ALKYLTHIO SUBSTITUENTS CONTAINING UP TO 4 CARBON ATOMS, OR UNSUBSTITUTED, OR HALOGEN-, AKYL- OR PHENYL-SUBSTITUTED OR BENZENE RING-CONDENSED, SATURATED OR UNSATURATED MONO- OR POLY-ALICYCLIC GROUP, OR UNOR ALKYL GROUP SUBSTITUTED BY SAID ALICYCLIC GROUP, OR UNSUBSTITUTED OR METHYL-, ETHYL- OR HALOGEN-SUBSTITUTED 5OR 6-MEMBERED HETEROCYCLIC RING GROUP CONTAINING OXYGEN, SULFUR OR NITROGEN ATOM; R4 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYL HAVING UP TO 4 CARBON WHEREIN X MAY BE HYDROGEN, HALOGEN, ALKYL, HALOALKYL, ATOMS OR HYDROGEN, OR A GROUP OF M (WHEREIN M IS A THE INDOLYACETIC ACID OF THE FORMULA (I) IS PREPARED BY REACTING A COMPOUND OF THE FORMULA, |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0250028-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004059130-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0250028-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4680411-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5324742-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4083981-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6930123-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4029798-A |
priorityDate | 1970-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.