| abstract |
NOVEL PROCESS FOR PREPARING 1-SUBSTITUTED BENZODIAZEPINE DERIVATIVES REPRESENTED BY THE FORMULA 1-(HO-CNH2N-),3-R2,5-R3,R1-2,3-DIHYDRO-1H-1,4- BENZODIAZEPIN-2-ONE WHEREIN R1 REPRESENTS HYDROGEN, HALOGEN, NITRO, C1-C4 ALKOXY, TRIFLUOROMETHYL OR CYANO; R2 REPRESENTS HYDROGEN, C1-C4 ALKYL, PHENYL OR ARALKYL; R3 REPRESENTS PYRIDL OR A GROUP OF THE FORMULA R4,R5-PHENYL (WHERE R4 AND R5 ARE INDEPENDENTLY HYDROGEN, HALOGEN, C1-C4 ALKYL, TRIFLUOROMETHYL OR CYANO); AND N REPRESENTS AN INTEGER OF 1 TO 4, WHICH COMPRISES REACTING AN AMINOPHENYLKETONE DERIVATIVE REPRESENTED BY THE FORMULA, 1-(HO-CNH2N-NH-),2-(R3-CO-),R1-BENZENE WHEREIN R1, R3 AND N ARE THE SAME AS DEFINED ABOVE, WITH AN OXAZOLID-2,5-DIONE DERIVATIVE REPRESENTED BY THE FORMULA 4-R2-OXAZOLIDINE-2,5-DIONE WHEREIN R2 IS THE SAME AS DEFINED ABOVE. THE 1-SUBSTITUTED BENZODIAZEPINE DERIVATIVES REPRESENTED BY THE FORMULA (I) HAVE PROMINENT EFFECTS AS TRANQUILIZER, MUSCLE RELAXANT, ANTISPASMODIC, ANTICONVULSANT AND HYPNOTIC. |