http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3812009-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_965942e7ea8701e32948bb3757b553b1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-225 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 |
| filingDate | 1972-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1974-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b21cae24abe8f33fdeaeb6b59c4a4363 |
| publicationDate | 1974-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-3812009-A |
| titleOfInvention | Stereospecific process for the preparation of l-3,4-dihydroxyphenylalanine (l-dopa)and analogs thereof |
| abstract | STEREOSPECIFIC PROCESS FOR THE PREPARATION OF L-2,4-DIHYDROXYPHENYLALANINE AND N-DERIVATIVES THEREOF FROM SUBSTRATE MATERIALS BY ENZYMATIC OXIDATION OF SAID SUBSTRATE MATERIALS WITH INSOLUBILIZED TYROSINASE FOLLOWED BY REDUCTION AND HYDROLYSIS OF THE OXIDATION PRODUCTS AS NEEDED. THE SUBSTRATE MATERIALS WHICH CAN BE USED IN THE PROCESS OF THIS INVENTION CAN BE L-TYROSINE AND CERTAIN N-DERIVATIVES THEREOF. ORDINARILY, THE BIOCATALYTIC OXIDATION OF THESE SUBSTRATE MATERIALS WILL GENEALLY YIELD AN OXIDATION PRODUCT CONSISTING ESSENTIALLY OF EITHER THE CORRESPONDING O-DIHYDRIC COMPOUND OF THE SUBSTRATE MATERIAL OR THE CORRESPONDING O-DIHYDRIC COMPOUNDS, THE BIOCATALYTIC OXIDATION OF THESE O-DIHYDRIC COMPOUNDS, THE SUPERNATANT CONTAINING THESE OXIDATION PRODUCTD IS SEPARATED FROM THE TYROSINASE IN ORDER TO PROVENT FURTHER OXIDATION OF THESE COMPOUNDS AND ESPECIALLY PRIOR TO REDUCTION OF MORE COMPLETELY OXIDIZED SUBSTRATE MATERIALS TO THE O-DIHYDRIC FORM. IN CERTAIN LIMITED INSTANCES, FOR EXAMPLE, WHERE N-ACETYL-L-TYROSINE IS THE SUBSTRATE MATERIAL, THE HYDROLYSIS OF N-ACETYL-L-3,4-DIHYDROXYPHENYLALANINE TO L-DOPA CAN BE ACCOMPLISHED ENZYMATICALLY THROUGH THE CONTACTING OF THE N-SUBSTITUTED COMPOUND WITH EITHER CARBOXYPEPTIDASE A OR ACYLASE. THE L-3,4-DIHYDROXYPHENYLAMINE THUS PREPARED HAS THERAPEUTIC VALUE IN THE TREATMENT OF PARKINSON''S DISEASE, AND OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0141613-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0141613-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5122461-A |
| priorityDate | 1972-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 270.