abstract |
A TERTIARY AMINO COMPOUND OF THE FORMULA 3-(Y-C(-R2)(-R3)-COO-),6,6-DI(CH3-),9-R1-9-AZABICYCLO- (3.3.1)NONANE WHEREIN R1 IS LOWER ALKYL, EACH OF R2 AND R3 IS PHENYL OR THIENYL AND Y IS HYDROGEN, HYDROXY OR LOWER ALKANOYLOXY, IS REACTED WITH A COMPOUND OF THE FORMULA R4-X, WHEREIN R4 IS LOWER ALKYL AND X IS AN ACID RESIDUE OF A PHARMACEUTICALLY ACCEPTABLE ACID. QUATERNARY AMMONIUM COMPOUNDS OF THE FORMULA 3-(Y-C(-R2)(-R3)-COO-),6,6-DI(CH3-),9-R1,9-R4- 9-AZONIABICYCLO(3.3.1)NONANE X(-) WHEREIN R1, R2, R3, R4, Y AND X ARE AS DEFINED ABOVE, ARE PRODUCED. THESE COMPOUNDS EXHIBIT POTENT PERIPHERAL ANTICHOLINERGIC ACTIVITY AND ARE SUBSTANTIALLY FREE FROM CENTRAL ANTICHOLINERGIC ACITVITY, 6,6,9,9-TETRAMETHYL-9AZONIABICYCLO(3.3.1)NONANE - 3-ALPHA (OR 3-BETA)-YL, ALPHA, ALPHA-DI(2-THIENYL)GLYCOLATE IODIDE AND 6,6,9,9TETRAMETHYL-9 - AZONIABICYCLO(3.3.1)NONANE - 3-ALPHA-YL ALPHA,ALPHA-DIPHENYL-GLYCOLATE IODIDE ARE PREFERRED. |