| abstract |
WHEREIN AR AND AR1, WHICH MAY BE IDENTICAL OR DIFFERENT FROM EACH OTHER, ARE EACH BICYCLIC AROMATIC FUSED-RING RADICALS, WHERE THE RING NOT DIRECTLY ATTACHED TO THE METHYLENE GROUP OR THENITROGEN ATOM OF THE PIPERAZINE NUCLEUS, RESPECTIVELY, IS AN ISOCYCLIC OR HETEROCYCLIC, SATURATED OR UNSATURATED RING, PREFERABLY 3,4-METHYLENEDIOXYPHENYL, INDANYL, TETRAHYDRONAPHTHYL, NAPHTHYL, 1,4 - BENZODIOXANYL OR CHROMANYL, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS ARE WELL AS THEIR SALTS ARE USEFUL AS CENTRAL NERVOUS SYSTEM DEPRESSANTS, ADRENOLYTICS, ANTIPHLOGISTICS AND ANTI-HISTAMINES. 1-(AR-CH2-CH(-CH3)-),4-AR1-PIPERAZINE COMPOUNDS OF THE FORMULA |