abstract |
AS ANTIVERAL AGENTS, 1-B-D-ARABINOFURANOSYLCYTOSINE-3'', 5''-CYCLIC PHOSPHATES AND DERIVATIVES THEREOF, E.G., ACYLATED 5-HALOGENATED AND N3-OXIDE ANALOGS. THE PRINCIPAL COMPOUND IS PREPARED BY CYCLIZING CYTIDYLIC ACID 2''(3'') MIXED ISOMERS TO THE 2'',3''-CYCLIC PHOSPHATE, WHICH IS DEHYDRATED TO YIELD THE 3'' PHOSPHATE, THE LATTER IN TURN UNDERGOING CYCLIZATION TO AFFORD THE 3'',5''-CYCLIC NULCLEOTIDE. NOVEL 4THIO ANALOGS OF THE PRINCIPAL COMPOUND VARIOUSLY EXHIBITING IN VITRO TUMOR INHIBITORY AND IMMUNOSUPPRESSANT PROPERTIES ARE ALSO DISCLOSED, AS ARE PRECURSORS USEFUL IN THEIR SYNTHESIS. |