abstract |
AMINO CITRIC ACIDS AND ESTERS, AND LACTAMS THEREOF, OF THE FORMULAS: R-OOC-C(-OH)(-CH2-COO-R)-CH(-NH2)-COO-R AND 2-(O=),4-(HO-),4,5-DI(R-OOC-)PYRROLIDINE WHEREIN ALL R GROUP ARE HYDROGEN OR THE SAME LOWER ALKYL, AND THE STEREOISOMERS, OPTICAL ANTIPODES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, WHICH COMPOUNDS INHIBIT FATTY ACID SYNTHESIS IN BIOLOGICAL SYSTEMS AND ARE THUS USEFUL IN TREATMENT OF OBESITY AND IN CORRECTING CONDITIONS OF LIPID ABNORMALITES. ADDITIONALLY, EXPOXIDE, AZIDE AND SULFONATE ESTER INTERMEDIATES ARE DISCLOSED. |