| abstract |
THE INVENTION CONCERNS AN IMPROVED PROCESS FOR THE MANUFACTURE OF CYSTINE-CONTAINING PEPTIDES FROM CYSTEINECONTAINING AMINOACID SEQUENCES WHOSE MERRCAPTO GROUPS ARE PROTECTED BY A GROUP OF THE FORMULA -CH2-NH-CO-R, IN WHICH CO-R REPRESENTS THE ACYL RADICAL OF A CARBOXYLIC ACID, WHEREIN THE S-PROTECTED CRYSTEINE-CONTAINING SEQUENCES ARE DIRECTLY OXIDIZED WITH IODINE TO YIELD THE CYSTINE DISULFIDE BOND. |