| abstract |
DESENSITIZING OR IMMUNIZING AGENTS ARE PROVIDED FOR TREATING HYPERSENSITIVE OR ALLERGIC CONDITIONS. MODIFIED ALLERGENIC MATERIAL IS PREPARED COMPRISING AN ALLERGENIC PROTEIN OR GLYCOPROTEIN CROSSLINKED INTERMOLECULARLY OR INTRAMOLECULARY WITH A POLYALDEHYDE, A POLYKETONE, A CARBODIIMIDE, AN EPIHALOHYDRIN, OR AN INORGANIC CYANATE. THE MODIFIED MATERIAL HAS REDUCED ALLERGENICITY RELATIVE TO THE UNCROSSLINKED ALLERGEN AND HAS THE ABILITY TO PRODUCE ANTIBODIES HAVING CROSS-SPECIFICITY FOR THE UNCROSSLINKED ALLERGENIC PROTEIN OR GLYCORPROTEIN. A METHOD FOR THEIR PRODUCTION IS DISCLOSED. |