| abstract |
A HECTEROCYCLIC ETHER OF THE FORMULA 1-(R1-O-A-),4-(R2-)-PIPERAZINE IN WHICH R1 IS 3-, 4- OR 6-ALKOXY-PYRIDYL-(2); 2-, 4- 5OR 6-ALKOXY-PYRIDYL-(3); 2- OR 3-ALKOXY-PYRIDYL-(4) WHICH HAVE 1-4 CARBON AOMS IN THE ALKOXY RADICAL: 3-, 4-, 5OR 6-METHYL-PYRIDYL-(2); 6 - ETHYL - PYRIDYL - (4)-; 2,6-DIMETHYL-PYRIDYL-(4); R2 IS PHENYL, O-TOLYL, M-TOLYL, P-TOLYL, O-AANISYL, M-ANISYL, P-ANISYL, O-CHLOROPHENYL, M-CHLOROPHENYL, P-CHLOROPHENYL, PYRIDYL (2), PYRIDYL (3), PYRIDYL (4); 2-CHLORO-4-METHYL-PHENYL, 2-CHLORO - 4 - METHOXYPHENYL AND 2-METHOXY-4 - METHYL - PHENYL, 6 - METHOXYPYRIDYL (2), 2-METHYL-PYRIDYL (4), 4,6-DIMETHYL-PYRIDYL (2) OR THEIR POSITION ISOMERS, AND A IS ALKYLENE HAVING FROM 2 TO 6 CARBON ATOMS WHEREIN THE SAME IS ETHYLENE, TRIMETHYLENE, 2-METHYL-ETHYLENE, 3-METHYL-ETHYLENE, TETRAMETHYLENE, 3-METHYL-TRIMETHYLENE, 2 - ETHYL - ETHYLENE, 1ETHYL-ETHYLENE, PENTAMETHYLENE, 4 - METHYL - TETRAMETHYLENE, 3-ETHYL-TRIMETHYLENE, 1-PROPYL - ETHYLENE, 1 - ISOPROPYL-ETHYLENE, 1,2-DIMETHYL - ETHYLENE, 1 HEXAMETHYLENE, 5METHYL-PETAMETHYLENE, 4 - ETHYL - TETRAMETHYLENE, 3 - PROPYL-TRIMETHYLENE, 2-BUTYL-ETHYLENE, 1 - BUTYL - ETHYLENE OR 1-METHYL-3-ETHYL-TRIMETHYLENE; AND PHYSIOLOGICALLY TOLERABLE ACID ADDITION SALTS THEREOF; THESE COMPOUNDS HAVE AN A-SYMPATHOLYTIC ACTION AND ARE USEFUL IN THE TREATMENT OF SHOCKS, MIGRAINE, HYPERTONIA AND BLOOD CIRCULATION DISORDERS OF THE EXTREMITIES. |