abstract |
THE PREPARATION OF QUININE, QUINIDINE, ISOMERS AND DERIVATIVES THEREOF FROM THE CORRESPONDINGLY SUBSTITUTED 4METHYLQUINOLINE AND 1-ACYL(OR 1-H)-3-VINYL(OR LOWER ALKYL)-4- PIPERIDINE ACETIC ACID ESTERS (OR ACETALDEHYDE) THROUGH ALTERNATIVE SERIES OF REACTION STEPS WHICH COMPRISE CONDENSATION, HALOGENATION, DECAYLATION, REDUCTION, CYCLIZATION AND HYDROXYLATION, IS DESCRIBED. ALSO DESCRIBED IS THE PREPARATION OF 1-ACYL(OR 1-H)-3-VINYL-4PIPERIDINEACETIC ACIDS AND ESTERS THEREOF AND 1-ACYL-3VINYL-4-PIPERIDINEACETALDEHYDE UTILIZING THE CORRESPONDING 7-ACYLDECAHYDRO-2H-PYRIDO(3,4-D)AZEPIN-2-ONE, PREPARED FROM -2ACYL-1,3,4,7,8,8A-HEXAHYDRO-6(2H)-ISOQUINOLONE. THE END PRODUCTS ARE USEFUL AS ANTIMALARIAL AND ANTIARRHYTHMIC AGENTS. |