http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3767684-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e70c0aeade92d7571d955d3b90ea06e |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
filingDate | 1971-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1973-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f9531516eb22f80849fbcade3b9a9f9 |
publicationDate | 1973-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-3767684-A |
titleOfInvention | Process for the preparation of 6,6-difluoro - 11beta,17alpha,21 - trihydroxypregn-4-ene - 3,20-dione and of its 16-methyl homologs |
abstract | ANTIINFLAMMATORY AND GLUCOCORTICOIDAL 6,6-DIFLUORO-11B, 17A, 21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE, OPTIONALLY SUBSTITUTED WITH AN A-OR B-METHYL AT C-16, THE CORRESPONDING 21-ESTERS AND RELATED 1,4-DIENES, ARE MADE FROM 6,6-DIFLUORO-3,17-DIACETOXYPREGNANE-20-ONES IN WHICH THE 5APOSITION ARE SUBSTITUTED WITH EITHER A FLUORINE OF A CHLORINE ATOM. INSTEAD OF THE 17A-ACETOXY GROUP, THE 17A-BYDROXYL CAN BE PRESENT. THE REACTION SEQUENCE INCLUDES HYDROLYSIS OF THE 3-ACETOXY GROUP AND BROMINATION AT C-21; OXIDATION OF THE C-3 HYDROXYL TO THE KETO GROUP; REACTION WITH SILVER ACETANE AND/OR SODIUM ACETATE WHICH GIVES THE $4-3,20-DIKETO-17A,21-DIHYDROXYSTERIOD 21-ACETATE; HY-* DROYLSIS OF THE 21-ACETOXY GROUP; AND MICROBIOLOGICAL HYDROXYLATION AT C-11. ALSO DESCIBED IS DEHYDROGENATION TO GIVE THE $1,4-TRIOL, CONVERSION TO THE CORRESPONDING 9AFLUORO STERIOD, ESPECIALLY 6,6,9A-TRIFULORO-11B,17A,21-TRIHYDROXY-16A-METHYLPREGNA-1,4-DIENE, AND ITS 21 ESTERS. METHODS FOR MAKING THE STARTING MATERIALS ALSO ARE DESCRIBED. |
priorityDate | 1970-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.