abstract |
NOVEL S-TRIAZINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND ANTI-ATHEROSCLEROTIC ACTIVITY AND OF THE FORMULA 2-R2,4-R1,6-R3-S-TRIAZINE WHEREIN R1 STANDS FOR PHENETHYLAMINO, ARALKYLAMINO, PYRROLIDINO, PIPERIDINO, 2-KETOPIPERAZINE-4-YL, CYCLOHEXYLAMINO OR STRAIGHT OR BRANCHED HEXYLAMINO; R2 STANDS FOR AMINO, ARALKYLAMINO, PYRROLIDINO, PIPERIDINO 2-KETOPIPERAZINE-4-YL, CYCLOHEXYLAMINO OR STRAIGHT OR BRANCHED HEXYLAMINO; AND R3 STANDS FOR STRAIGHT OR BRANCHED ALKYL OF FROM 1-6 CARBON ATOMS, PYRROLIDINO, PIPERIDINO, 2-KETOPIPERAZINE4-YL OR NR4R5 IN WHICH R4 IS HYDROGEN OR STRAIGHT OR BRANCHED ALKYL OF FROM 1-6 CARBON ATOMS AND R5 IS STRAIGHT OR BRANCHED ALKYL WITH FROM 1-6 CARBON ATOMS, WITH THE PROVISO THAT (A) WHEN R1 IS PHENETHYLAMINO, R2 IS AMINO AND R3 IS STRAIGHT OR BRANCHED ALKYL OF FROM 2-6 CARBON ATOMS; (B) WHEN R1 IS ARALKYLAMINO, PYRROLIDINO, PIPERIDINO OR 2-KETOPIPERAZINE-4-YL, R2 IS THE SAME OR ONE OF SAID GROUPS AND R3 IS STRAIGHT OR BRANCHED ALKYL OF FROM 1-6 CARBON ATOMS; (C) WHEN R1 IS CYCLOHEXYLAMINO OR STRAIGHT OR BRANCHED HEXYLAMINO, R2 IS THE SAME OR ONE OF SAID GROUPS AND R3 IS STRAIGHT OR BRANCHED ALKYL OF FROM 1-6 CARBON ATOMS; AND (D) WHEN R1 IS CYCLOHEXYLAMINO, R2 IS AMINO AND R3 IS PYRROLIDINO, PIPERIDINO, 2-KETOPIPERAZINE-4-YL OR NR4R5, WHEREIN R4 AND R5 HAVE THE ABOVE MEANING. |