| abstract |
NOVEL HEPTA- AND OCTAPEPTIDES OF THE FORMULA: 2-(R1-CO-),1-(NH2-C(=NH)-NH-(CH2)3-CH(-NH-R)-CO-NH-CH(- CH(-CH3)2)-CO-NH-CH(-CH2-(1,4-PHENYLENE)-OH)-CO-R2-NH- CH(-CH2-C<(-NH-CH=N-CH2-))-CO-)PYRROLIDINE WHEREIN R IS HYDROGEN, SUCCINYL, L-ASPARTYL, SARCOSYL, LSERYL, SUCCINAMYL, L-PROLYL, GLYCYL, OR D- OR L-ASPARAGINYL; R1 IS AN L-ALANINE, L- OR D-LEUCINE, GLYCINE, LISOLEUCINE OR B-ALANINE RESIDUE; AND R2 IS L-VALYL, OR LALANYL UPON INTRAVENOUS INFUSION TO ANIMALS INHIBIT BLOOD PRESSURE RESPONSE TO ANGIOTENSIN AMIDE. |