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filingDate 1971-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1973-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa09bfaf498cf358757c7101a9145b61
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publicationDate 1973-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-3746701-A
titleOfInvention Method for the production of benzodiazepine derivatives
abstract COMPOUNDS OF THE FORMULA 2-(O=),5-(C6H5-),7-O2N-1,2-DIHYDRO-3H-1,4-BENZODIAZEPINE WHEREIN PH REPRESENTS A SUBSTITUTED OR UNSUBSTITUTED PHENYL GROUP ARE PREPARED BY REACTING A COMPOUND OF THE FORMULA 4-NO2,2-(C6H5-CO-),1-NH2-BENZENE WITH A COMPOUND OF THE FORMULA XCH2C(OR)3 WHEREIN X REPRESENTS A HALOGEN ATOM AND R REPRESENTS A LOWER ALKYL GROUP, TO PRODUCE A COMPOUND OF THE FORMULA 4-NO2,2-(C6H5-CO-),1-(X-CH2-C(-O-R)=N-)BENZENE REACTING SAID COMPOUND III WITH AMMONIA TO PRODUCE A COMPOUND OF THE FORMULA 4-NO2,2-(R-OOC-CH2-N=C(-C6H5)-),1-NH2-BENZENE AND SUBJECTING SAID COMPUND II TO A RING-CLOSURE REACTION. COMPOUNDS I ARE USEFUL AS TRANQUILIZER OR HYPNOTIC AGENTS OR AS INTERMEDIATES FOR OTHER MEDICINES. COMPOUNDS III ARE NOVEL PRODUCTS.
priorityDate 1970-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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