abstract |
ANTI-INFLAMMATORY AGENTS OF THE FORMULA 1,2-(-(Y)N-CH(-(CH2)P-AR)-CO-N(-ALK-B)-),(X)M-BENZENE WHEREIN X MAY BE HYDROGEN, HALOGEN, ALKYL, HALOALKYL, ALKOXY, HALOALKOXY, HYDROXY, ALKYLTHIO, HALOALKYLTHIO, NITRO, ALKYLSULFONYL, AINO, ALKANOYLAMINO, OR MONO- OR DIALKYLAMINO WHEREIN ANY OF THE FOREGOING ALKYL OR SUBSTITUTED ALKYL RADICALS MAY CONTAIN UP TO 8 CARBON ATOMS, M MAY BE 0, 1, 2, 3 OR 4, Y MAY BE -O-, -S-, -SO-, -SO2-, -CH2-, OR -CH2CH2-, N MAY BE 0 OR 1, ALK MAY BE A BASIC NITROGEN CONOF UP TO 6 CARBON ATOMS, B MAY BE A BASIC NITROGEN CONTAINING RADICAL, P MAY BE 1, 2 OR 3, AND AR MAY BE PHENYL, X-SUBSTITUTED PHENYL, PYRIDYL, THIENYL, FURYL, NAPHTHYL, OR ALKYLENEDIOXYPHENYL, AND PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION OR QUATERNARY AMMONIUM SALTS THEREOF AND N-OXIDES AND PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF. |