abstract |
4 - (3 - (SUBSTITUTED AMINO) - 2 - HYDROXYPROPOXY)1,2,5-THIADIAZOLE COMPOUNDS, SUBSTITUTED IN THE 3-POSITION OF THE THIADIAZOLE NUCLEUS EXHIBIT B-ADRENERGIC BLOCKING PROPERTIES AND THUS ARE USEFUL IN THE MANAGEMENT OF ANGINA PECTORIS ARE DESCRIBED. THE PRODUCTS ARE PREPARED BY REACTION OF 3-CARBOXY-4-ALLYLOXY-1,2,5-THIADIAZOLE WITH N-BROMOSUCCINIMIDE FOLLOWED BY ESTERIFICATION TO GIVE THE AKYL ESTER OF 3-CARBOXY-4-(3-BROMO-2-HYDROXYPROPOXY)-1,2,5-THIADIAZOLE WHICH UPON TREATMENT WITH AN AMINE FORMS A 3-CARBAMOYL-4-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXY)-1,2,5-THIADIAZOLE. |