abstract |
COMPOUNDS OF THE FORMULA: 1,2-(-N(-C(=S)-O-AR)-Y-X-),(R)N-BENZENE WHEREIN: X IS SULPHUR, OXYGEN, NR1, CO, CHR1 OR CR1 WHEREIN R1 IS HYDROGEN OR STRAIGHT OR BRANCHED CHAIN LOWER ALKYL, Y IS A STRAIGHT OR BRANCHED CHAIN ALIPHATIC MOIETY OF1 TO X 3 CARBON ATOMS, OR SAID ALIPHATIC MOIETY LINKED TO X BY A DOUBLE BOND, R IS HYDROGEN, HALOGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLMERCAPTO OR TRIFLUOROMETHYL, N IS 1, 2 OR 3, AND AR IS AN UNSUBSTITUTED OR SUBSTITUTED AROMATIC MOIETY, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA: 1,2-(-NH-Y-X-),(R)N-BENZENE WHEREIN C, Y, R AND N ARE AS ABOVE DEFINED WITH A THIOCARBONIC ACID ESTER HAIDE OF THE FORMULA: HAL-CS-O-AR WHEREIN HAL IS HALOGEN AND AR IS AS ABOVE DEFINED. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS FOR THE TREATMENT OF FUNGAL INFECTIONS WHICH ARE PATHOGENIC TO HUMANS AND ANIMALS. |