| abstract |
A method as set forth for screening chemical agents and compounds to determine their usefulness in the treatment of circulatory system diseases and to enable distinguishing the anticoagulant and antithrombotic characteristics of the same. The method consists of a plurality of interrelated steps including the evaluation of the agent or compound on an exposed laboratory animal mesentery. Also included are tests on streaming potential in blood vessels, both in vivo and in vitro. In addition, the method includes checking the effect of the tested substances on electro-osmosis and evaluating the effect of the substance undergoing test on the charge of blood cells. Still further, the test includes checking the effect of the substance on the transport of ions across blood vessel walls and on the sorption and desorption of ions with respect to the circulatory system. In addition, the effect of the substance on destruction of various cells and proteins in blood is determined. The above characteristics are evaluated to determine the antithrombotic, antiatherogenic usefulness of the substance undergoing test. |