| abstract |
21-HALO-STERIODS OF THE FORMULA 5-F,16-(H3C-),17-(X-CH2-CO-),11-(HO-)ANDROST-4-EN-3-ONE WHERE A IS THE C1 ATOM AND B IS THE C2 ATOM WHEREIN -A-B-IS ONE OF THE GROUPS-CH2-CH2-CH=CH-, OR-CC1=CH, AND X IS A HALOGEN ATOM, HAVE EXCELLENT ANTI-INFLAMMATORY ACTIVITY, ESPECIALLY TOPICAL ANTI-INFLAMMATORY ACTIVITY, WITH A LOW INCIDENCE OF SIDE EFFECTS, E.G., SODIUM RETENTION, AND POTASSIUM EXCRETION. |