abstract |
INDAZOLE-3-CARBOXYLIC AMIDES OF THE GENERAL FORMULA 1-Q,3-(R1-N(-R2)-CO-),5,6-DI(CH3-O-)-1H-INDAZOLE WHEREIN R1 AND R2 REPRESENT INDEPENDENTLY HYDROGEN, STRAIGHT CHAINED OR BRANCHED ALKYL OF UP TO 16 CARBON ATOMS, CYCLOALKYL, NAPHTHYL, PHENYL OR ARALKYL GROUP, WHERE THE PHENYL AND ARALKYL GROUPS MAY BE SUBSTITUTED WITH ONE OR TWO LOWER ALKYL, ALKOXY, TRIFLUOROMETHYL OR HALO SUBSTITUENT, FURTHER R1 AND R2 MAY FORM TOGETHER WITH THE ADJACENT NITROGEN ATOM AND OPTIONALLY WITH A FURTHER NITROGEN ATOM A 5 OR 6 MEMBERED HETEROCYCLIC RADICAL, Q REPRESENTS HYDROGEN, ALKALI METAL OR AN ACYL GROUP OF 1 TO 4 CARBON ATOMS HAVE BEEN PREPARED. THE NEW COMPOUNDS POSSESS VALUABLE PHARMACOLOGICAL ACTIVITIES, FIRST ALL THEY ARE POTENT ANTI-INFLAMMATORY AND ANALGESIC AGENTS. |