| abstract |
COMPOUNDS OF THE FORMULA 2-R1,8-((3-(R2,R3-PHENYL),2-(O=)IMIDAZOLIDIN-1-YL)-CH2- CH2-)-1,4-DIOXA-8-AZASPIRO(4,5)DECANE WHEREIN R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, (LOWER) ALKYL, PHENYL AND BENZYL, AND R2 AND R3 EACH REPRESENT A MEMBER SELECTED FROM THE GROUP CONSISTING OF CHLORO, BROMO, IODO AND TRIFLUOROMETHYL; AND THE PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS THEREOF EXHIBIT TRANQUILIZING ACTIVITY AND ARE USEFUL AS TRANQUILIZERS AND ANTIEMETIC AGENTS IN MAMMALS. |