abstract |
A 2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE DERIVATIVE, WHICH IS USEFUL AS TRANQUILLIZER, HYPNOTIC, MUSCLE-RELAXANT AND ANTICONVULSANT, IS PRODUCED BY HYDROLYZING A 2-(DIOXOPIPERAZINO)-BENZOPHENONE DERIVATIVE. THE 2-(DIOXOPIPERAZINO)-BENZOPHENONE DERIVATIVE IS PREPARED BY TREATING A 3-PHENYL-INDOLE-2-CARBOXYLIC ACID ESTER DERIVATIVE WITH A REACTIVE ESTER OF CYANOMETHYLALCOHOL, AND REDUCING THE RESULTING 1-CYANOMETHYL COMPOUND, AND THEN CONTACTING THE RESULTING PIPERAZINO-INDOLE DERIVATIVE WITH A SUITABLE OXIDIZING AGENT. |