abstract |
THIS INVENTION RELATES TO NOVEL X-RAY CONTRAST AGENTS PARTICULARLY FOR USE IN THE CEREBROSPINAL CAVITIES, COMPRISING NON-IONIC ALKANOLS CARRYING AT LEAST ONE N-BONDED SECONDARY OR TETIARY AMIDE GROUP AND HAVING AT LEAST TWO HYDROXYL GROUPS AND AT LEAST ONE IODINE ATOM IN THE MOLECULE. PARTICULARLY USEFUL COMPOUNDS INCLUDE THE N-HY DROXYALKYL GROUPS, TRI- AND TETRA-IODOBENZENE CARRYING CARBAMOYL, ACYLAMINO AND/OR ACYLAMINOMETHYL SUBSTITUENTS AND HAVING AT LEAST TWO HYDROXYL GROUPS IN THE MOLECULE AND AT LEAST ONE N-HYDROXYALKYL GROUP. PARTICULARLY PREFERRED COMPOUNDS COMPRISE 2,4,6-TRIIODOBENZAMIDES WHICH MAY BE 3- AND/OR 5-SUBSTITUTED WITH A VARIETY OF GROUPS. THE COMPOUNDS ALL SHOW MARKEDLY LOW TOXICITIES AND A NUMBER SHOW VERY HIGH LEVELS OF WATER SOLUBILITY. |