| abstract |
Novel pharmaceutical compositions containing bis-basic ethers and thioethers of fluorenone and fluorene selected from a base of the formula WHEREIN: Z is oxygen or H2; each Y is oxygen or sulfur; and each X is A. the group WHEREIN A is alkylene of two to about eight carbon atoms and separates the amino nitrogen thereof and Y by an alkylene chain of at least two carbon atoms, each R and R1 is hydrogen, (lower)alkyl, cycloalkyl of three to six ring carbon atoms, alkenyl of three to six carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R and R1 taken together with the nitrogen to which they are attached is pyrrolidino, piperidino, N(lower)alkylpiperazino, or morpholino; or B. the group WHEREIN N IS AN INTEGER OF 0 TO 2, M IS 1 OR 2 AND R2 is hydrogen, (lower)alkyl, or alkenyl of three to six carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group; or a pharmaceutically acceptable acid addition salt of said base. These compositions can be used as pharmaceuticals for preventing or inhibiting a viral infection. |