abstract |
The preparation of piperidyl-steroids having an oxygencontaining group in the 16-position which comprises reacting C16bromo-cyanamides, in a predominantly aprotic and polar medium with an alkali metal salt of a lower aliphatic carboxylic acid or of benzoic acid, isolating the resulting 16-acyloxy-cyanamide and then reducing this compound to remove the nitrile group. |